Cited 12 time in webofscience Cited 9 time in scopus

Preliminary Study on Alginate/NIPAM Hydrogel-based Soft Microrobot for Controlled Drug Delivery Using Electromagnetic Actuation and Near-Infrared Stimulus

Title
Preliminary Study on Alginate/NIPAM Hydrogel-based Soft Microrobot for Controlled Drug Delivery Using Electromagnetic Actuation and Near-Infrared Stimulus
Authors
Lee, HyoryongChoi, HyunchulLee, MikyoungPark, Sukho
DGIST Authors
Lee, Hyoryong; Choi, Hyunchul; Lee, Mikyoung; Park, Sukho
Issue Date
2018-12
Citation
Biomedical Microdevices, 20(1), 1-9
Type
Article
Article Type
Article
Author Keywords
Controlled drug releasingElectromagnetic actuationHydrogel-based microrobotMagnetic nanoparticlesNear-infrared stimulusTemperature responsive
Keywords
FABRICATIONCELL
ISSN
1387-2176
Abstract
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery. In this study, we propose a spring type medical microrobot that can be manipulated by an electromagnetic actuation (EMA) system and respond to an external stimulus (NIR). Additionally, we verified its feasibility with regard to targeting and drug delivery. There exist various methods of fabricating a spring type microrobot. In this study, we adopted a simple method that entails using a perfluoroalkoxy (PFA) microtube and a syringe pump. Moreover, we also used a hydrogel mixture composed of natural alginate, N-Isopropylacrylamide (NIPAM) for temperature responsiveness, and magnetic nanoparticles (MNPs) for electromagnetic control. Then, we fabricated a spring type alginate/NIPAM hydrogel-based soft microrobot. Additionally, we encapsulated doxorubicin (DOX) for tumor therapy in the microrobot. To verify the feasibility of the proposed spring type hydrogel-based soft microrobot’s targeting and drug delivery, we developed an EMA and NIR integrated system. Finally, we observed the swelling and deswelling of the soft microrobot under NIR stimulation and verified the EMA controlled targeting. Moreover, we implemented a control function to release the encapsulated anticancer drug (DOX) through the swelling and deswelling of the soft microrobot by NIR, and evaluated the feasibility of cancer cell therapy by controlling the release of the drug from the soft microrobot. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
URI
http://hdl.handle.net/20.500.11750/9445
DOI
10.1007/s10544-018-0344-y
Publisher
Springer US
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringETC1. Journal Articles
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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