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  Department of New Biology Senescence-Associated Mechanism Lab

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The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias

Article
The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias
  • 2020-06
  • Lee, Davin. (2020-06). The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias. doi: 10.3389/fnins.2020.00489
  • Frontiers Media S.A.
  • View : 459
  • Download : 191

Identification of SYK inhibitor, R406 as a novel senolytic agent

Article
Identification of SYK inhibitor, R406 as a novel senolytic agent
  • Cho, Hyun-Ji ; 
  • Yang, Eun Jae ; 
  • Park, Joon Tae ; 
  • Kim, Jae-Ryong ; 
  • Kim, Eok-Cheon ; 
  • Jung, Kyong-Jin ; 
  • Park, Sang Chul ; 
  • Lee, Young-Sam
  • 2020-05
  • Cho, Hyun-Ji. (2020-05). Identification of SYK inhibitor, R406 as a novel senolytic agent. doi: 10.18632/aging.103135
  • Impact Journals
  • View : 829
  • Download : 167

Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration

Article
Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration
  • Bae, Ju-Hyeon ; 
  • Hong, Mingi ; 
  • Jeong, Hyeon-Ju ; 
  • Kim, Hyebeen ; 
  • Lee, Sang-Jin ; 
  • Ryu, Dongryeol ; 
  • Bae, Gyu-Un ; 
  • Cho, Sung Chun ; 
  • Lee, Young-Sam ; 
  • Krauss, Robert S. ; 
    • et al
  • 2020-08
  • Bae, Ju-Hyeon. (2020-08). Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. Journal of Cachexia, Sarcopenia and Muscle, 11(4), 1089–1103. doi: 10.1002/jcsm.12563
  • Wiley
  • View : 776
  • Download : 172
Article
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
  • Kuk, Myeong Uk ; 
  • Kim, Jae Won ; 
  • Lee, Young-Sam ; 
  • Cho, Kyung A. ; 
  • Park, Joon Tae ; 
  • Park, Sang Chul
  • 2019-03
  • Kuk, Myeong Uk. (2019-03). Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. doi: 10.14348/molcells.2018.0352
  • 한국분자세포생물학회
  • View : 804
  • Download : 0
Article
Quantification of Autophagy During Senescence
  • 2019
  • Park, Joon Tae. (2019). Quantification of Autophagy During Senescence. doi: 10.1007/978-1-4939-8931-7_14
  • Humana Press Inc.
  • View : 700
  • Download : 0
Article
Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
  • Park, Joon Tae ; 
  • Lee, Young-Sam ; 
  • Cho, Kyung A. ; 
  • Park, Sang Chul
  • 2018-11
  • Park, Joon Tae. (2018-11). Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence. doi: 10.1016/j.arr.2018.08.003
  • Elsevier Ireland Ltd
  • View : 831
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Article
A crucial role of ROCK for alleviation of senescence-associated phenotype
  • Park, J.T. ; 
  • Kang, H.T. ; 
  • Park, C.H. ; 
  • Lee, Young Sam ; 
  • Cho, K.A. ; 
  • Park, Sang Chul
  • 2018-06
  • Park, J.T. (2018-06). A crucial role of ROCK for alleviation of senescence-associated phenotype. doi: 10.1016/j.exger.2018.02.012
  • Elsevier BV
  • View : 984
  • Download : 0

Systematic identification of an integrative network module during senescence from time-series gene expression

Article
Systematic identification of an integrative network module during senescence from time-series gene expression
  • Park, Chihyun ; 
  • Yun, So Jeong ; 
  • Ryu, Sung Jin ; 
  • Lee, Soyoung ; 
  • Lee, Young-Sam ; 
  • Yoon, Youngmi ; 
  • Park, Sang Chul
  • 2017-03
  • Park, Chihyun. (2017-03). Systematic identification of an integrative network module during senescence from time-series gene expression. BMC Systems Biology, 11(1). doi: 10.1186/s12918-017-0417-1
  • BIOMED CENTRAL LTD
  • View : 945
  • Download : 147
Article
Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome
  • Kang, Hyun Tae ; 
  • Park, Joon Tae ; 
  • Choi, Kobong ; 
  • Choi, Hyo Jei Claudia ; 
  • Jung, Chul Won ; 
  • Kim, Gyu Ree ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-06
  • Kang, Hyun Tae. (2017-06). Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome. Aging Cell, 16(3), 541–550. doi: 10.1111/acel.12584
  • WILEY
  • View : 994
  • Download : 0
Article
Chemical screening identifies ATM as a target for alleviating senescence
  • Kang, Hyun Tae ; 
  • Park, Joon Tae ; 
  • Choi, Kobong ; 
  • Kim, Yongsub ; 
  • Choi, Hyo Jei Claudia ; 
  • Jung, Chul Won ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-06
  • Kang, Hyun Tae. (2017-06). Chemical screening identifies ATM as a target for alleviating senescence. Nature Chemical Biology, 13(6), 616-+. doi: 10.1038/nchembio.2342
  • NATURE PUBLISHING GROUP
  • View : 1157
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Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota

Article
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota
  • Choi, Jeong-Yun ; 
  • Patra, Amritaj ; 
  • Yeom, Mina ; 
  • Lee, Young-Sam ; 
  • Zhang, Qianqian ; 
  • Egli, Martin ; 
  • Guengerich, F. Peter
  • 2016-09
  • Journal of Biological Chemistry, v.291, no.40, pp.21063 - +
  • American Society for Biochemistry and Molecular Biology Inc.
  • View : 1011
  • Download : 73
Article
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase kappa
  • Kim, Jae-Kwon ; 
  • Yeom, Mina ; 
  • Hong, Jin-Kyung ; 
  • Song, Insil ; 
  • Lee, Young-Sam ; 
  • Guengerich, F. Peter ; 
  • Choi, Jeong-Yun
  • 2016-10
  • Chemical Research in Toxicology, v.29, no.10, pp.1741 - 1754
  • American Chemical Society
  • View : 879
  • Download : 0
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