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Closed-Loop Neuromodulation for Parkinson’s Disease: Current State and Future Directions

Closed-Loop Neuromodulation for Parkinson’s Disease: Current State and Future Directions
Kim, SamhwanKang, SeongtakKim, JinmoLee, DoyoungLee, JunghyupKim, SangheeJang, Kyung-InOh, Yong-SeokRah, Jong-CheolHuh, Man SeungPaek, Sun HaChoi, Ji-Woong
DGIST Authors
Lee, JunghyupJang, Kyung-InOh, Yong-SeokChoi, Ji-Woong
Issue Date
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, 1-1
Article Type
Author Keywords
Closed-loop systemDeep brain stimulationNeuromodulationParkinson&#x2019s disease.
AminesBrainNeuronsClinical therapyDeep brain stimulationDirect assessmentElectrical stimulationsInformation processing techniqueMovement disordersPsychiatric disordersTechnological advancementNeurosurgery
Deep brain stimulation (DBS) refers to a neurosurgical process in which electrical stimulation is delivered via electrodes implanted within deep brain regions. DBS has become the most established clinical therapy for patients with movement disorders, although recent studies have investigated its application in a broad range of neurological and psychiatric disorders as well. Moreover, DBS has proven effective in controlling symptoms in patients with Parkinson’s disease (PD). While early DBS systems were capable of stimulation only, technological advancements have allowed for the direct assessment of dysfunctional brain activity and subsequent stimulation of the pathological circuitry. DBS can also be combined with neurochemical stimulation to address decreased concentrations of dopamine in the brain. Given that both electrical and neurochemical treatments for PD aim to rectify abnormalities in neural activity, the general term “neuromodulation” is considered more accurate and comprehensive. Recent improvements in signal detection and information processing techniques have provided further insight into PD mechanisms, which may aid in the development of personalized biomarkers and in the prediction of symptoms. In this comprehensive review, we discuss various aspects of neuromodulation in patients with PD, including basic theories, stimulation paradigms, and current challenges in the field. IEEE
Institute of Electrical and Electronics Engineers Inc.
Related Researcher
  • Author Oh, Yong-Seok Molecular Psychiatry Lab
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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Department of Information and Communication EngineeringIntegrated Nano-Systems Laboratory1. Journal Articles
Department of Robotics EngineeringBio-integrated Electronics Lab1. Journal Articles
Department of Brain and Cognitive SciencesMolecular Psychiatry Lab1. Journal Articles
Department of Information and Communication EngineeringCSP(Communication and Signal Processing) Lab1. Journal Articles

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