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Long-term in-vivo recording performance of flexible penetrating microelectrode arrays

Long-term in-vivo recording performance of flexible penetrating microelectrode arrays
Jang, Jae-WonKang, Yoo NaSeo, Hee WonKim, BoilChoe, Han KyoungPark, Sang HyunLee, Maan-GeeKim, Sohee
Issued Date
Journal of Neural Engineering, v.18, no.6, pp.066018
Author Keywords
flexible penetrating microelectrode array (FPMA)neural interfacelong-term recordingsignal-to-noise ratio (SNR)
Objective. Neural interfaces are an essential tool to enable the human body to directly communicate with machines such as computers or prosthetic robotic arms. Since invasive electrodes can be located closer to target neurons, they have advantages such as precision in stimulation and high signal-To-noise ratio (SNR) in recording, while they often exhibit unstable performance in long-Term in-vivo implantation because of the tissue damage caused by the electrodes insertion. In the present study, we investigated the electrical functionality of flexible penetrating microelectrode arrays (FPMAs) up to 3 months in in-vivo conditions. Approach. The in-vivo experiment was performed by implanting FPMAs in five rats. The in-vivo impedance as well as the action potential (AP) amplitude and SNR were analyzed over weeks. Additionally, APs were tracked over time to investigate the possibility of single neuron recording. Main results. It was observed that the FPMAs exhibited dramatic increases in impedance for the first 4 weeks after implantation, accompanied by decreases in AP amplitude. However, the increase/decrease in AP amplitude was always accompanied by the increase/decrease in background noise, resulting in quite consistently maintained SNRs. After 4 weeks of implantation, we observed two distinctive issues regarding long-Term implantation, each caused by chronic tissue responses or by the delamination of insulation layer. The results demonstrate that the FPMAs successfully recorded neuronal signals up to 12 weeks, with very stably maintained SNRs, reduced by only 16.1% on average compared to the first recordings, although biological tissue reactions or physical degradation of the FPMA were present. Significance. The fabricated FPMAs successfully recorded intracortical signals for 3 months. The SNR was maintained up to 3 months and the chronic function of FPMA was comparable with other silicon based implantable electrodes. © 2021 Institute of Physics Publishing. All rights reserved.
IOP Publishing
Related Researcher
  • 최한경 Choe, Han Kyoung 뇌과학과
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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Appears in Collections:
Department of Brain Sciences Laboratory of Animal Behavior and Circadian rhythm 1. Journal Articles
Department of Robotics and Mechatronics Engineering Neural Interfaces & MicroSystems Lab 1. Journal Articles
Department of Robotics and Mechatronics Engineering Medical Image & Signal Processing Lab 1. Journal Articles


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